DNA binding, nuclease activity and cytotoxicity studies of Cu(II) complexes of tridentate ligands.

Synthesis, Characterization, DNA Binding and Nuclease Activity of Cobalt(II) Complexes of Isonicotinoyl Hydrazones

Cobalt(II)  complexes of isonicotinoyl hydrazones of two series of ligands have been synthesized and characterized on the basis of elemental analyses, molar conductance, magnetic moment, mass, IR, UV spectral data. Electrochemical behavior of ligands and complexes has been investigated by using cyclic voltammetry. Cyclic voltammetric studies reveal that the oxidation/reduct...

Cu(II) and Zn(II) complexes with unsymmetrical tetradentate Schiff base ligands: Synthesis, spectral characterization, antimicrobial assay and DNA binding property

The reaction of copper(II) chloride and zinc(II) chloride with N-(2-methylphenyl)-3-(1'-salicylaldehydene-2'-imine-ethane)-butanamide(H2L2a) or (MPSB), N-(2-methylphenyl)-3-(1'-(3'-methoxysalicylaldehydene-2'-imine-ethane)-butanamide (H2L2b) or (MPMSB) and N-(2-methylphenyl)-3-(1'-(2'-hydroxyacetylene-2'-imine-ethane)-butanamide (H2L2c) (MPHB) leads to the formation of a series of new complexes...

Novel Pt(II) Complex and Its Pd(II) Aanalogue. Synthesis, Characterization, Cytotoxicity and DNA-interaction

The ability of small molecules to perturb the natural structure and dynamics of nucleic acids is intriguing and has potential applications in cancer therapeutics. This work reports the synthesis, characterization, cytotoxicity and DNA-binding studies of two cytotoxic and intercalative [M(bpy)(pyrr-dtc)]NO3 complexes (where M = Pt(II) and Pd(II), bpy = 2,2´-bipyridine and pyrr-dtc = p...

Studies on Spectral characterization, crystal structure nuclease activity and CYTOTOXICITY of DInuclear copper(II) complexes formed with tridentate ligands

Interaction of Novel Ni2+, Cu2+ and VO2+ Complexes of a Tridentate Schiff Base Ligand with DNA, BSA and their Cytotoxic Activity

In this research, the interaction of [CuL(DMF)], [NiL(DMF)] and [VOL(DMF)] (where L = ((E)-4-((2-amino-5-nitrophenylimino)methyl)benzene-1,3-diol)) complexes derived from tridentate Schiff base ligand with bovine serum albumin (BSA) and DNA was investigated via electronic absorption and fluorescence spectroscopy. The Ultraviolet-Visible (UV-Vis) spectra exhibited an isosbestic point for the com...